Saddle up, partner

Partner up to invade

Partner up to invade A secretory complex and a cytoskeletal polarity protein cooperate to make tumor cells more invasive, according to new work from Sakurai-Yageta et al. To burrow into nearby tissue, tumor cells create membrane protrusions called invadopodia. Within invadopodia, vesicles accumulate that contain metalloproteinase enzymes needed to degrade the extracellular matrix. Because a sec...

Ending up with the right partner.

HIV self-testing to scale up couples and partner testing.

HIV self-testing is benefi ting from substantial investment in implementation research from major donors and rapid development of evidence-based policy and practice. The reason for such excitement around HIV self-testing is three-fold. First, diagnosing 90% of all people with HIV—the fi rst step of the UN’s goal to end the HIV epidemic by 2030—will require a substantial increase in testing serv...

Will the Real “Natural Trading Partner” Please Stand Up?

Adherents of the “natural trading partner” hypothesis argue that forming a PTA is more likely to raise welfare if member countries already trade disproportionately with each other. Opponents of the hypothesis claim that the opposite is true: welfare is likely to be higher if member countries trade less with each other. This paper shows that neither analysis is correct and that the “natural trad...

SADDLE POINT VARIATIONAL METHOD FOR DIRAC CONFINEMENT

A saddle point variational (SPV ) method was applied to the Dirac equation as an example of a fully relativistic equation with both negative and positive energy solutions. The effect of the negative energy states was mitigated by maximizing the energy with respect to a relevant parameter while at the same time minimizing it with respect to another parameter in the wave function. The Cornell pot...